Barrett’s Oesophagus surveillance

Endoscopy

Useful Management Information

Australian clinical practice guidelines for the diagnosis and management of Barrett's oesophagus and early oesophageal adenocarcinoma (2015) recommended screening endoscopy schedules.

  • No dysplasia on endoscopic assessment and Seattle protocol biopsy
    • Short (< 3 cm) segment – repeat endoscopy in 3–5 years
  • Long (≥ 3 cm) segment – repeat endoscopy in 2–3 years

If there has been previous low-grade dysplasia, see low-grade dysplasia protocol.

Seattle protocol—biopsy of any mucosal irregularity and quadrantic biopsies every 2 cm unless known or suspected dysplasia then quadrantic biopsies every 1 cm.

Indefinite for dysplasia on biopsy

The changes of indefinite for dysplasia on biopsy should be confirmed by a second pathologist, ideally an expert gastrointestinal pathologist. If indefinite for dysplasia is confirmed, then the following endoscopic surveillance is recommended:

  • Repeat endoscopy in 6 months with Seattle protocol biopsies for suspected dysplasia (biopsy of any mucosal irregularity and quadrantic biopsies every 1 cm) on maximal acid suppression
  • If repeat shows no dysplasia, then follow as per non-dysplastic protocol
  • If repeat shows low-grade or high-grade dysplasia or adenocarcinoma, then follow protocols for these respective conditions
  • If repeat again shows confirmed indefinite for dysplasia, then repeat endoscopy in 6 months with Seattle protocol biopsies for suspected dysplasia.

Low-grade dysplasia on biopsy
The changes of low-grade dysplasia on biopsy should be confirmed by a second pathologist, ideally an expert gastrointestinal pathologist. If low-grade dysplasia is confirmed, then the following endoscopic surveillance is recommended (or refer to an expert centre for assessment):

  • Repeat endoscopy every 6 months with Seattle protocol biopsies for dysplasia (biopsy of any mucosal irregularity and quadrantic biopsies every 1 cm).
  • If 2 consecutive 6-monthly endoscopies with Seattle dysplasia biopsy protocol show no dysplasia, then consider reverting to a less frequent follow up schedule.

High-grade dysplasia or adenocarcinoma on biopsy
Referral to a centre that has integrated expertise in endoscopy, imaging, surgery and histopathology

NB: If a patient has been fully investigated 2 years prior to referral, then the referrer and the receiving clinician will need to exercise clinical decision making in triaging and/or value in repeat endoscopy/colonoscopy procedures

Minimum Referral Criteria

Category 1
  • See Useful Management Information section for guideline information
Category 2
  • See Useful Management Information section for guideline information
Category 3
  • See Useful Management Information section for guideline information

If your patient doesn't meet the minimum referral criteria

  • Consider other treatment pathways or an alternative diagnosis
  • If the patient does not meet the criteria for referral but the referring practitioner believes the patient requires specialist review, a clinical override may be requested:
    • Please explain why (e.g. warning signs or symptoms, clinical modifiers, uncertain about diagnosis, etc.)
  • Please note that your referral may not be accepted or may be redirected to another service.

Essential Referral Information

  • Previous endoscopic procedures (date, report and histology)

If a specific test result is unable to be obtained due to access, financial, religious, cultural or consent reasons a Clinical Override may be requested. This reason must be clearly articulated in the body of the referral.

Additional Referral Information

  • No additional referral information
Published 12 May 2021

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